An update on New Delhi metallo-β-lactamase-1 and its inhibitors
10.16438/j.0513-4870.2019-1049
- VernacularTitle:超级细菌NDM-1及其抑制剂的研究进展
- Author:
Wen-bin JIN
1
;
Jiang LI
2
;
Jiao LI
2
;
Ling-yun CHEN
1
;
An-guo HOU
1
;
Yun-shu MA
1
Author Information
1. Yunnan University of Chinese Medicine, Kunming 650500, China; Key Laboratory of Applied Drug Delivery System and Preparation Technology, Kunming 650500, China
2. Yunnan University of Chinese Medicine, Kunming 650500, China
- Publication Type:Research Article
- Keywords:
superbug;
italic>β-lactamase;
New Delhi metallo-β-lactamase;
inhibitor
- From:
Acta Pharmaceutica Sinica
2020;55(6):1157-1165
- CountryChina
- Language:Chinese
-
Abstract:
The rapid development of antibiotic resistance among bacterial pathogens has threatened to take humans back to the "pre-antibiotic era". The New Delhi metallo-β-lactamase (NDM-1) hydrolyzes nearly all β-lactam antibiotics including carbapenems. Bacterial strains carrying blaNDM-1 gene are termed "superbugs" and clinical inhibitors of NDM-1 have not yet been identified. Discovery of novel NDM-1 inhibitors is a challenging but rewarding research area. This review focuses on the structural characteristics and catalytic mechanisms of NDM-1, and comprehensively summarizes the development of NDM-1 inhibitors in order to facilitate the further development of NDM-1 inhibitors.
