Effects of non-surgical periodontal treatment on level of vaspin and TNF-α in gingival crevicular fluid of type 2 diabetic patients with chronic periodontitis
10.12016/j.issn.2096-1456.2017.06.004
- VernacularTitle:牙周基础治疗对2型糖尿病伴慢性牙周炎患者龈沟液丝氨酸蛋白酶抑制剂和肿瘤坏死因子-α水平的影响
- Author:
WANG Lihong
1
;
ZHANG Wenbiao
1
;
XI Lijun
1
;
BAO Aiqin
1
;
HUANG Shiguang
2
Author Information
1. Department of Stomotology Shenzhen Futian Hospital of Traditional Chinese Medicine
2. Faculty of Dentistry School of Medicine Jinan University
- Publication Type:Journal Article
- Keywords:
Visceral adipose tissue-derived serine protease inhibitor;
Tumor necrosis factor-alpha;
Gingival crevicular fluid;
Periodontitis;
Type 2 diabetes mellitus
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2017;25(6):360-364
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the changes of vaspin and TNF-α levels in gingival crevicular fluid (GCF) of type 2 diabetic (T2DM) patients with chronic periodontitis (CP) after non-surgical periodontal treatment.
Methods:60 subjects were divided into 4 groups: DM-CP group (patients with both T2DM and CP, n=15); CP group (CP patients without T2DM, n=15); DM group (T2DM patients without CP, n=15), and CTRL group (systemically and periodontally healthy individuals, n=15). The clinical parameters of periodontal tissue and GCF were measured before and 8 weeks after non-surgical periodontal treatment.
Results:The levels of vaspin and TNF-α were measured by ELISA. The levels of vaspin and TNF-α in CP group were significantly higher than those in CTRL group (P < 0.05), while the levels of vaspin and TNF-α in CP group were significantly decreased after treatment (P < 0.05). There was a statistically significant positive correlation between the total amount of vaspin and the total amount of TNF-α, the level of HbA1c, gingival index (GI) and probing depth (PD) (P < 0.05).
Conclusion :The results shows that vaspin and TNF-α are greatly decreased in periodontitis after non-surgical periodontal treatment. It suggests that vaspin and TNF-α in GCF may serve as inflammatory markers for the diagnosis and prognosis of diabetes and periodontitis.
- Full text:牙周基础治疗对2 型糖尿病伴慢性牙周炎患者龈沟液丝氨酸蛋白酶抑制剂和肿瘤坏死因子-α水平的影响.pdf
