Role of bile acid metabolism and related receptors in the development and progression of nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2020.06.040
- VernacularTitle:胆汁酸代谢及其受体在非酒精性脂肪性肝病发生发展中的作用
- Author:
Yang ZHANG
1
;
Junxiang LI
;
Yunliang WANG
Author Information
1. Graduated School of Beijing University of Chinese Medicine, Beijing 100029, China
- Publication Type:Research Article
- Keywords:
non-alcoholic fatty liver disease;
cholic acids;
enterohepatic circulation
- From:
Journal of Clinical Hepatology
2020;36(6):1374-1377
- CountryChina
- Language:Chinese
-
Abstract:
Enterohepatic circulation plays an important role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Bile acid is the basic substance of enterohepatic circulation and plays an important role in lipid metabolism, intestinal flora regulation, and host immunity. This article summarizes the research advances in bile acid which acts as a signal molecule to activate bile acid receptors in the liver and intestine, such as farnesoid X receptor, G protein-coupled receptor 5, pregnane X receptor, and vitamin D receptor, and is thus involved in the pathogenesis of NAFLD. It is expected to develop effective drugs for the treatment of NALFD based on the above targets, but there is still a need for further exploration.
