Predictors for Diarrhea After Administration of Naldemedine: Analysis Focusing on the Administration Period of Opioid Analgesics Before the Start of Naldemedine

Junya HASHIZUME; Emi RYU; Seiichi NOSE; Kei MIYANAGA; Reiko KISHIKAWA; Tadahiro NAKAMURA; Takahiro MURO; Yukinobu KODAMA; Haruna YAMASHITA; Koji ISHII; Hitoshi SASAKI

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Predictors for Diarrhea After Administration of Naldemedine: Analysis Focusing on the Administration Period of Opioid Analgesics Before the Start of Naldemedine

VernacularTitle:ナルデメジン導入後の下痢発現に関する予測因子─ナルデメジン導入前のオピオイド鎮痛薬の投与期間に着目した解析─
Author: Junya HASHIZUME ¹ ; Emi RYU ¹ ; Seiichi NOSE ² ; Kei MIYANAGA ¹ ; Reiko KISHIKAWA ¹ ; Tadahiro NAKAMURA ¹ ; Takahiro MURO ¹ ; Yukinobu KODAMA ¹ ; Haruna YAMASHITA ¹ ; Koji ISHII ² ; Hitoshi SASAKI ³
Author Information

1. Department of Hospital Pharmacy, Nagasaki University Hospital
2. Nagasaki University Palliative Care Center
3. Department of Anesthesiology, Nagasaki University Hospital
Keywords: opioid-induced constipation; naldemedine; diarrhea; predictors
From:Palliative Care Research 2020;15(2):101-109
CountryJapan
Language:Japanese
Abstract: Purpose: Naldemedine is a peripheral µ-opioid receptor antagonist, including the treatment of opioid-induced constipation (OIC) . However, diarrhea is known as its side effect. We conducted a study focusing on the administration period of opioid analgesics before the start of naldemedine to clear predictors of diarrhea due to Naldemedine. Method: All data were retrospectively collected from the electronic medical record system. We investigated patients who initially administrated naldemedine at Nagasaki University Hospital from June 1 2017 to March 31 2019. Result: One hundred thirty-two patients were subject of investigation. The incidence of diarrhea was 25.0%. The result of the multivariate analysis showed that significant predictors of diarrhea were associated with the opioid analgesics usage period longer than 7 days before naldemedine initiation (odds ratio: 3.76, 95% confidence interval: 1.53-9.20, p=0.004). Discussion: When naldemedine was used for OIC, diarrhea may be avoided by using within 7 days after opioid analgesics.