Research progress of receptor protein FUNDC1 in mitophagy
10.16571/j.cnki.1008-8199.2020.05.017
- VernacularTitle: 线粒体自噬中受体蛋白FUNDC1研究进展
- Author:
Yi-nan LUO
1
;
Qiao-meng QIU
1
;
Zhong-qiu LU
1
;
Yong-ming YAO
2
Author Information
1. Department of Emergency, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
2. Trauma Research Center, Fourth Medical Center of the Chinese PLA General Hospital, Beijing 100048,China
- Publication Type:Journal Article
- Keywords:
mitochondria;
mitophagy;
receptor protein;
FUNDC1;
regulatory mechanism
- From:
Journal of Medical Postgraduates
2020;33(5):537-542
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria, which play an important role in cell metabolism, stress response and cell death, are the key organelles that regulate the energy balance of cells. Under the influence of internal and external environment, damaged or senescent mitochondria pose a serious threat to cell survival. Mitophagy refers to the selective elimination of dysfunctional mitochondria to maintain the homeostasis of the intracellular environment. FUN14 domain containing 1 (FUNDC1) is a newly discovered mitophagy receptor protein, which plays an important regulatory role in mediating mitophagy. This paper mainly reviews the recent research progress of FUNDC1 regulation mechanism and its pathophysiological significance in mitophagy.
