The study of relationship between acute myocardial injury and coagulation function in patients with COVID-19
10.16571/j.cnki.1008-8199.2020.06.013
- VernacularTitle: 新型冠状病毒肺炎患者急性心肌损伤与凝血功能的关系探讨
- Author:
Ying XU
1
;
Dan XIE
2
;
Ya-jun QIAN
1
;
Wen-kui YU
1
;
Jian TANG
1
Author Information
1. Department of Critical Care Medicine, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China
2. Department of Pulmonary Disease, Kunshan Hospital of Traditional Chinese Medicine, Suzhou 215300, Jiangsu,China
- Publication Type:Journal Article
- Keywords:
2019-novel coronavirus pneumonia;
acute myocardial injury;
coagulation function;
D-dimer
- From:
Journal of Medical Postgraduates
2020;33(6):623-626
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the relationship between acute myocardial injury（AMI） and coagulation function in patients with COVID-19.MethodsA retrospective study was carried out to record the general and laboratory data of 133 patients diagnosed with COVID-19 who were hospitalized in Wuhan TongJi Guanggu Hospital, Wuhan, Hubei Province from February 10 to February 29, 2020. The laboratory data includes blood routine, liver and renal function, myocardial infarction tests, coagulation function, inflammatory factors, hypersensitive C-reactive protein, procalcitonin etc. The patients were divided into two groups according to cardiac troponin I（TNI）34.2 ug/L. The differences of general conditions and laboratory data between the two groups were compared. Besides, the correlation between coagulation function and coagulation function, and the ROC curve of D-dimer in AMI were conducted .ResultsAmong the 133 patients, 9 (6.77%) had cTnI greater than 34.2 μg/L, and 124 (93.23%) had normal cTnI. There were significant differences between the two groups in age, COPD history, blood routine (neutrophil count, lymphocyte count, platelet count), myoglobin, liver function (direct bilirubin, indirect bilirubin), cytokines (IL-2 receptor, IL-6, IL-8, IL-10, TNF-α), coagulation function (PT, PTA, D-dimer). D-dimer level was positively correlated with TnI, CK-MB and myoglobin levels. The cut off value of D-dimer was 2.35 μg/ml in acute myocardial injury.ConclusionAcute myocardial injury in COVID-19 patients may be related to coagulation dysfunction. Therefore, monitoring of coagulation function dynamically, screening of thrombus and starting anticoagulant and antiplatelet therapy timely help to reduce acute myocardial injury.
