Diagnostic performance of adenosine deaminase for tuberculous pleural effusion.
10.13602/j.cnki.jcls.2019.06.03
- VernacularTitle:腺苷脱氨酶诊断结核性胸腔积液的性能验证
- Author:
Tingxu HAN
1
;
Nannan ZHOU
2
;
Bin SUN
2
;
Mei DONG
2
;
Ting XU
3
;
Lili JIAO
4
;
Haixia LI
4
;
Chen ZHANG
1
;
Juan LIU
1
;
Guohong WANG
1
;
Guobin XU
1
Author Information
1. Department of Clinical Laboratory, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute
2. Department of Clinical Laboratory, The Eighth Medical Center Of PLA General Hospital
3. Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University
4. Department of Clinical Laboratory, Peking University First Hospital
- Publication Type:Journal Article
- Keywords:
tuberculous pleural effusion；adenosine deaminase；cutoff value；Meta analysis
- From:
Chinese Journal of Clinical Laboratory Science
2019;37(6):413-417
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To verify the diagnostic value of adenosine deaminase (ADA) for tuberculous pleural effusion.
Methods:Forty-three cases with tuberculous pleural effusion and 163 cases with non-tuberculous pleural effusion were consecutively collected. The concentration of ADA in pleural effusion was determined by enzyme kinetics. The receiver operating characteristic (ROC) analysis curve was used to calculate the optimal cut-off value of ADA for diagnosing tuberculous pleural effusion based on the control groups with non-tuberculous pleural effusion. Meanwhile, the specificity and sensitivity of ADA level for diagnosis of tuberculous pleural effusion were compared with previous reports.
Results:The concentration of ADA in tuberculous pleural effusion (median 52.5 U/L) was significantly higher than that in non-tuberculous pleural effusion (median 9.8 and 10.6 U/L) (P＜0.05). With a cut-off level for ADA of 25 U/L, the diagnostic sensitivity and specificity was 88.0% and 91.0%, respectively. A system review analyzed data from 17 studies with QUADAS score ≥10 points and revealed the cut-off value of ADA to be （28.1±12.8） U/L (range 10.2 to 55.8 U/L) with a sensitivity of 89% (95%CI: 87% to 91%) and a specificity of 89% (95%CI: 88% to 91%).
Conclusion:The specificity and sensitivity of ADA for diagnosis of tuberculous pleural effusions should be up to over 85%, while the cut-off value of ADA from different literature reports were diverse.
