Clinical characteristics and distribution of peripheral T lymphocyte subsets in patients with schistosomal hepatic diseases in Suzhou City
10.16250/j.32.1374.2019196
- VernacularTitle:苏州地区血吸虫性肝病患者临床特征及外周血T 淋巴细胞亚群分布
- Author:
Yun-Hai YAO
1
;
Wei-Feng ZHAO
1
;
Jian-He GAN
1
Author Information
1. Department of Infectious Diseases/Intensive Care Unit of Hepatology, The First Hospital Affiliated of Soochow University, Suzhou 215006, China
- Publication Type:Journal Article
- Keywords:
Schistosomal liver disease;
Clinical characteristic;
T lymphocyte subsets;
Suzhou City
- From:
Chinese Journal of Schistosomiasis Control
2020;32(2):154-158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and the distribution of peripheral blood T lymphocyte sub-sets in patients with schistosomal hepatic cirrhosis in Suzhou City. Methods A total of 32 inpatients with liver diseases due to advanced schistosomiasis at the Department of Infectious Diseases, The First Affiliated Hospital of Soochow University from January 2016 to January 2018 were recruited and assigned into the infection and non-infection groups according to presence of co-infections, and 20 old healthy volunteers served as controls. Venous blood samples were collected on the day of admission, and the proportions of CD4+ T cells, CD8+ T cells, regulatory T (Treg) cells and Th17 cells were detected in peripheral blood using flow cytometry. Results Most patients with liver disorders due to advanced schistosomiasis were admitted to hospital in Suzhou City because of portal hypertension-associated complications, with a high prevalence of co-infections (59.38%, 19/32). The proportions of peripheral CD4+ and CD8+ T cells and Th17 cells were all significantly lower in patients with liver disorders due to advanced schistosomiasis than in controls (t = −5.111, −4.470 and −2.749, all P < 0.05), and a higher proportion of Treg cells was detected in patients than in controls (t = 5.628, P < 0.05). In addition, there were significant differences among the infection group, non-infection group and controls in terms of the percentage of CD4+ T cells, CD8+ T cells, Th17 cells and Treg cells (F = 15.837, 16.594, 9.290 and 27.866, all P < 0.05). Conclusion Portal hypertension-associated complications are predominantly seen in patients with liver diseases due to advanced schistosomiasis at admission in Suzhou City, and co-infections are common. Imbalance of peripheral T cell subsets is detected in patients with liver diseases due to advanced schistosomiasis in Suzhou City.
