Expression and clinical significance of ONECUT2 gene in human gastric cancer
10.3872/j.issn.1007-385x.2020.04.015
- VernacularTitle:ONECUT2基因在人胃癌中的表达及其临床意义
- Author:
DING Peng
1
;
YAN Jie
1
;
QIN Yanru
1
Author Information
1. Department of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China
- Publication Type:Journal Article
- Keywords:
ONECUT;
gastric cancer (GC);
bioinformatics;
database;
prognosis
- From:
Chinese Journal of Cancer Biotherapy
2020;27(4):433-439
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract] Objective: To investigate the expression of one cut homeobox 2, OC-2 (ONECUT2) gene in human gastric cancer and its clinical significance. Methods: Based on bioinformatics technology, Oncomine, GEPIA, CCLE and EBI databases were searched to analyze the expression level of OC-2 in gastric cancer (GC) and other tumors. Kmplot database was used to verify the correlation between OC-2 expression and the prognosis of gastric cancer patients. STRING database was used to construct proteinprotein interaction network (PPI network), and the co-expressed genes of OC-2 related with gastric cancer were also analyzed. Results: The expression of OC-2 was generally up-regulated in different kinds of tumors with differential OC-2 expression. The expression level of OC-2 increased significantly in gastric cancer tissues and cells (all P<0.05) and might be irrelevant with tissue type and tumor stage (all P>0.05). The expression level of OC-2 was correlated with prognosis of gastric cancer patients. The median overall survival (40.0 vs 26.5 months) and median disease-free survival (26.2 vs 16.1 months) of gastric cancer patients with low OC-2 expression was significantly longer than those patients with high expression (both P<0.01). Fifteen co-expressed genes of OC-2 were obtained; the PPI network predicted 30 functional proteins interacting with OC-2, among which 11 proteins were also related to the occurrence and development of gastric cancer. After Pearson correlation analysis, 4 proteins that closely and positively related to OC-2 were identified: PDX1 (R=0.49), CREB1 (R=0.31), MAPK1 (R=0.26) and CTSS (R=0.25). Conclusion: OC-2 may play an important role in the occurrence and development, as well as invasion and metastasis of gastric cancer, which is expected to become a new target for the diagnosis and treatment of gastric cancer, and also an important indicator for the prognosis prediction of gastric cancer patients.
- Full text:20200415.pdf
