Expression changes of S100 family proteins and their functional significances in renal cancer
10.11665/j.issn.1000-5048.20200214
- VernacularTitle:S100家族蛋白与肾癌关系的研究进展
- Author:
Siyi CHEN
1
;
Maode LAI
Author Information
1. 中国药科大学基础医学与临床药学学院
- Publication Type:Journal Article
- Keywords:
S100 protein;
renal cancer;
renal cell carcinoma;
progress
- From:
Journal of China Pharmaceutical University
2020;51(2):223-230
- CountryChina
- Language:Chinese
-
Abstract:
Renal cell carcinoma is a common type malignant tumor of the urinary system. The global incidence of renal cancer is 2. 2%. S100 proteins are involved in the regulations of proliferation, differentiation, apoptosis, and Ca2+ homeostasis, etc. S100 proteins are often closely associated with tumor progression. This review lists the expression changes of S100s and their functional significances in renal cancers, providing a new direction for the researches and treatments of renal cancer. The interpretation of S100 in the regulation of VHL/HIF signaling pathways should be a future direction.
