Recent advances in the discovery of dengue virus inhibitors
10.16438/j.0513-4870.2019-0787
- VernacularTitle:抗登革病毒药物化学研究新进展
- Author:
Ling-xin HOU
1
;
Han JU
1
;
Peng ZHAN
1
;
Xin-yong LIU
1
Author Information
1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
- Publication Type:Research Article
- Keywords:
engue fever;
engue virus;
engue hemorrhagic fever;
rug discovery
- From:
Acta Pharmaceutica Sinica
2020;55(4):669-678
- CountryChina
- Language:Chinese
-
Abstract:
Dengue fever is one of the most important vector-borne human diseases caused by mosquito vector Aedes aegypti and Aedes albopictus. Dengue virus can cause dengue fever, dengue hemorrhagic fever and dengue shock syndrome. There are no approved drugs for the treatment of dengue disease so far. In this paper, combined with the latest progress in the research of anti-dengue virus, the new progress in the research of anti-dengue virus drugs was reviewed from the aspects of protease inhibitors, virus polymerase inhibitors, entry inhibitors, virus replication-related host factor inhibitors, capsid protein inhibitors and nucleic acid inhibitors.
