Progress on IFV drug targets and small molecule inhibitors
10.16438/j.0513-4870.2019-0737
- VernacularTitle:抗流感病毒药物靶标及其小分子抑制剂的研究进展
- Author:
Si-yu XIU
1
;
Jian ZHANG
1
;
Han JU
1
;
Rui-fang JIA
1
;
Bing HUANG
2
;
Peng ZHAN
1
;
Xin-yong LIU
1
Author Information
1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
2. Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan 250012, China
- Publication Type:Research Article
- Keywords:
influenza virus;
antiviral drug;
rug target;
rug design;
small molecule inhibitor
- From:
Acta Pharmaceutica Sinica
2020;55(4):611-626
- CountryChina
- Language:Chinese
-
Abstract:
The outbreak of the influenza viruses (IFV) caused significant harm to our health and life. Human infections caused by pathogenic avian influenza virus (AIV) have continually brought great panic and death threats to people all over the world. With the in-depth study of the biological characteristics of influenza viruses and the rapid development of drug discovery screening technology, a new generation of anti-influenza drug targets and their inhibitors have been continuously discovered, providing more options for the treatment of influenza. From the point of view of medicinal chemistry, this review summarizes and discusses current endeavours towards the discovery and development of novel inhibitors and also provides examples illustrating new methodologies that contribute to the identification of novel anti-influenza drugs.
