Advances in research on HBV inhibitors based on new targets (2): RNase H and others
10.16438/j.0513-4870.2019-0711
- VernacularTitle:基于新靶标的HBV抑制剂研究进展 (2): RNase H及其他靶标
- Author:
Fen-ju WEI
1
;
Yue MA
1
;
Ji YU
1
;
Hai-yong JIA
2
;
Xin-yong LIU
1
;
Peng ZHAN
1
Author Information
1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
2. School of Pharmacy, Weifang Medical University, Weifang 261053, China
- Publication Type:Research Article
- Keywords:
hepatitis B;
rug target;
RNase H;
inhibitor;
rug design
- From:
Acta Pharmaceutica Sinica
2020;55(4):566-574
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B has become one of the major diseases which seriously affect people's health and social development. Hepatitis B, with high incidence and long disease course, cannot be cured by approved drugs such as the nucleoside analogues. Therefore, the discovery of safe and efficient novel HBV inhibitors is of great significance. From the point of view of medicinal chemistry, we summarized and discussed current endeavours towards the discovery and development of anti-HBV agents of RNase H and other novel target inhibitors with various scaffolds or distinct mechanisms of action, besides the existing capsid protein inhibitors.
