Advances in research on HBV inhibitors based on new targets (1): capsid protein inhibitors
10.16438/j.0513-4870.2019-0710
- VernacularTitle:基于新靶标的HBV抑制剂研究进展 (1): 衣壳蛋白抑制剂
- Author:
Yue MA
1
;
Fen-ju WEI
1
;
Ji YU
1
;
Hai-yong JIA
2
;
Xin-yong LIU
1
;
Peng ZHAN
1
Author Information
1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
2. School of Pharmacy, Weifang Medical University, Weifang 261053, China
- Publication Type:Research Article
- Keywords:
HBV;
non-nucleos(t)ide;
capsid protein inhibitors;
medicinal chemistry;
rug target
- From:
Acta Pharmaceutica Sinica
2020;55(4):554-565
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) capsid protein plays an important role in the life cycle, thus becoming an ideal target for drug design. Capsid protein inhibitors can exert a synergistic antiviral effect with nucleoside drugs by inhibiting the replication of HBV. This paper reviews the research progress of capsid protein inhibitors with different structural types from the perspective of medicinal chemistry.
