From SARS to COVID-19: pathogens, receptor, pathogenesis and principles of the treatment
10.3760/cma.j.cn112151-20200318-00220
- VernacularTitle: 从病原体、受体分布、病理改变和治疗原则分析严重急性呼吸综合征与新型冠状病毒感染疾病
- Author:
Xia WANG
1
;
Yanqing DING
2
Author Information
1. Huayin Pathology Test Center of Southern Medical University, Guangzhou 510700, China
2. Departmentof Pathology, Nanfang Hospital, Nanfang Medical University, Guangzhou 510515,China
- Publication Type:Journal Article
- From:
Chinese Journal of Pathology
2020;49(0):E012-E012
- CountryChina
- Language:Chinese
-
Abstract:
COVID-19 is an infectious disease caused by 2019-nCoV and characterizes as an atypical pneumonia. Since 2019-nCoV is a newly emerging virus, the pathogenesis of COVID-19 is not well known. Most patients had a self-limited course, and some became severe even death. In this review, the authors compared two coronavirus outbreaks during the past two decades: the SARS-CoV and 2019-nCoV. Among the biological nature of the pathogens, viral receptor distribution on the human cells, and the pathological findings in the targeted organs and clinical features of the patients with the diseases, found similarities and differences between the two diseases. Due to the shared receptor ACE2 and the pathological similarities of the SARS-CoV and 2019-nCoV diseases. They proposed a pathogenesis model for COVID-19. Like the SARS-CoV disease, COVID-19 is a systematic disease and targets the lungs, vasculatures, and the immune system. The basic pathogenesis involves two interlinked processes: a severe lung inflammation and immune deficiency, both of which are related to an inappropriate immune response and over-production of cytokines. Thus, treatment approaches should include antiviral and anti-proinflammatory cytokines, anti-infectious and life support therapies, especially in patients with severe diseases.
