Effects of neutrophils-to-lymphocytes ratio on heart valve calcification in maintenance hemodialysis patients
10.16571/j.cnki.1008-8199.2020.03.012
- VernacularTitle: 维持性血液透析患者中性粒细胞与淋巴细胞比值对心脏瓣膜钙化的影响
- Author:
Ming-ming ZHANG
1
;
Yu-ying ZHANG
1
;
Tian-yu LI
1
;
Dan CHEN
1
;
Sen ZHANG
1
;
Xue-rong WANG
1
;
Li HAO
1
;
De-guang WANG
1
Author Information
1. Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui, China
- Publication Type:Journal Article
- Keywords:
maintenance hemodialysis;
cardiac valve calcification;
neutrophils-to- lymphocytes
- From:
Journal of Medical Postgraduates
2020;33(3):280-284
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveCardiovascular disease (CVD) is the main cause of morbidity and mortality in patients with hemodialysis (HD) end-stage renal disease (ESRD). This paper analyzes and discusses the relationship between neutrophils-to-lymphocytes ratio (NLR) and heart valve calcification (CVC) in maintenance hemodialysis (MHD) patients to provide theoretical basis for the prevention and treatment of CVC.MethodsThe demographic data, relevant clinical indicators and laboratory examination results of 135 patients with MHD in the Second Hospital of Anhui Medical University were retrospectively analyzed to calculate the NLR value. Echocardiography was used to detect the incidence of CVC in the patients, and they were divided into calcification group and non-calcification group. The correlation between NLR value and CVC in MHD patients was analyzed, and the independent risk factors of CVC were discussed by using Logistic regression.ResultsAmong the 135 MHD patients, CVC was found in 59 cases (43.7%). Compared with the non-calcification group, patients in the calcification group showed significant increases in age, dialysis age, high-sensitivity c-reactive protein (HsCRP), ALP and NLR, with statistically significant differences (P<0.05). Correlation analysis showed that CVC was positively correlated with dialysis age, age, HsCRP, ALP and NLR (P<0.05). Logistic regression showed that dialysis age (OR=1.017, P=0.030), ALP (OR=1.001, P=0.043) and NLR>5.02 (OR=17.709, P=0.046) were independent risk factors for heart valve calcification in MHD patients.ConclusionThe incidence of heart valve calcification is high in MHD patients, and NLR is an independent risk factor for it.
