Advances in the study of brain function changes in inflammatory bowel disease
10.16571/j.cnki.1008-8199.2019.07.017
- VernacularTitle: 炎症性肠病脑功能变化研究进展
- Author:
Yu-lin YANG
1
;
Chang LIU
1
;
Fang-yu WANG
1
Author Information
1. Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University / General Hospital of Eastern Theater Command,PLA,Nanjing 210002,Jiangsu,China
- Publication Type:Journal Article
- Keywords:
brain-gut-microbiome axis;
inflammatory bowel disease;
crohn's disease;
ulcerative colitis;
brain functional magnetic resonance
- From:
Journal of Medical Postgraduates
2019;32(7):755-759
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD) is a chronic non-specific inflammatory disorder that commonly affects gastrointestinal tract. The cause is not clear. Previous studies have shown that IBD patients often suffer from anxiety and depression, which may be associated with impaired brain structure and function and changes in gut microbiome. Based on these findings, many researches indicate brain-gut-microbiome axis may play an important role in the occurrence and development of IBD. Blood oxygenation level dependent functional magnetic resonance (BOLD-fMRI) can detect brain function area with special response accurately and objectively, which helps to investigate the changes of brain function and its pathogenesis in IBD patients. This article reviews the current status and future prospects in IBD brain function changes based on the brain-gut-microbiome axis.
