Role of protease and self-digestion in the pathogenesis of inflammatory bowel disease
10.16571/j.cnki.1008-8199.2019.06.001
- VernacularTitle: 蛋白酶与自身消化在炎症性肠病发生机制中的作用与启示
- Author:
Hui-min WU
1
;
Fang-yu WANG
1
Author Information
1. Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University / General Hospital of Eastern Theater Command,PLA,Nanjing 210002,Jiangsu,China
- Publication Type:Journal Article
- Keywords:
inflammatory bowel disease;
peptic ulcer diseases;
proteases;
self-digestion
- From:
Journal of Medical Postgraduates
2019;32(6):561-565
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel diseases (IBD) are non-specific inflammatory diseases of unknown cause, mainly including ulcerative colitis and Crohn’s disease. IBDs have some similarities to peptic ulcer diseases (PUD) in clinical manifestations, histopathological changes and treatment strategies, and therefore pepsin might have a similar effect on both PUD and IBD. Recent studies show that “self-digestion” induced by digestive enzymes, especially trypsin, may play an important role in the development and progression of IBD. This article focuses on the role of mucosal barrier injury induced by trypsin and self-digestion in the formation of digestive ulcer in IBD.
