CT diagnosis and differential diagnosis of renal cell carcinoma associated with Xp11.2 translocation/TFE gene fusions
10.16571/j.cnki.1008-8199.2019.05.016
- VernacularTitle: XP11.2易位TFE基因融合相关性肾癌的CT表现特征及鉴别诊断
- Author:
Sui CHEN
1
;
Zi-jian CHEN
2
;
Jian-rui LI
2
;
Shou-ju WANG
1
;
Guang-ming LU
2
Author Information
1. College of Medical Imaging,Xuzhou Medical University,Xuzhou 221004,Jiangsu,China
2. Department of Medical Imaging,General Hospital of Eastern Theater Command,PLA,Nanjing 210002,Jiangsu,China
- Publication Type:Journal Article
- Keywords:
renal cell carcinoma;
computer tomography;
XP11.2 translocation;
TFE gene fusion
- From:
Journal of Medical Postgraduates
2019;32(5):532-535
- CountryChina
- Language:Chinese
-
Abstract:
Objective XPll.2/TFE RCC is an independent subtype of renal cell carcinoma, which is rare. The aim of this study is to investigate the CT features of Xp11.2/TFE RCC and improve the accuracy of diagnosis. MethodsCT findings of 30 cases from August 2009 to September 2017 of Xp11.2/TFE RCC from Eastern War Zone General Hospital, including location, density, edge, enhancement degree, lymphatic metastasis and others. They were analyzed respectively and compared with those of ccRCC. ResultsThe differences in CT values between tumors and renal cortex and renal medulla was statistically significant different phases (P< 0.01). Most of patients with Xp11.2/TFE RCC are younger, about (36.4±17.7) years old. Females are more common, accounting for about 70% compared with ccRCC(50%). CT plan scan showed slightly higher density, about (45.2±8.9)HU vs (34.1±4.4)HU, high calcification rate, about 46.7% % vs 10.0% and CT scan with contrast agent showed gradual enhancement. The difference all were statistically significant(P<0.05). ConclusionXPll.2/ has certain CT characteristics. Combined with CT and clinical manifestation of patients, it is helpful to improve the accuracy of preoperative diagnosis. Methods CT findings of 30 cases from August 2009 to September 2017 of Xp11.2/TFE RCC from Eastern War Zone General Hospital, including location, density, edge, enhancement degree, lymphatic metastasis and others. They were analyzed respectively and compared with those of ccRCC. Results The differences in CT values between tumors and renal cortex and renal medulla was statistically significant different phases (P< 0.01). Most of patients with Xp11.2/TFE RCC are younger, about (36.4±17.7) years old. Females are more common, accounting for about 70% compared with ccRCC(50%). CT plan scan showed slightly higher density, about (45.2±8.9)HU vs (34.1±4.4)HU, high calcification rate, about 46.7% % vs 10.0% and CT scan with contrast agent showed gradual enhancement. The difference all were statistically significant(P<0.05). Conclusion XPll.2/ has certain CT characteristics. Combined with CT and clinical manifestation of patients, it is helpful to improve the accuracy of preoperative diagnosis.
