A clinical research of prone position ventilation in the treatment of moderate and severe ARDS caused by acute paraquat poisoning
10.16571/j.cnki.1008-8199.2019.01.015
- VernacularTitle: 俯卧位通气治疗急性百草枯中毒致中重度急性呼吸窘迫综合征的临床研究
- Author:
Liang LI
1
;
Zhao-rui SUN
1
;
Yi REN
1
;
Xin CHEN
1
;
Zhi-zhou YANG
1
;
Shi-nan NIE
1
Author Information
1. Department of Emergency,General Hospital of Eastern Theater Command,PLA,Nanjing 210002, Jiangsu, China
- Publication Type:Journal Article
- Keywords:
acute paraquat poisoning； acute respiratory distress syndrome；prone position ventilation；oxygenation；prognosis
- From:
Journal of Medical Postgraduates
2019;32(1):69-72
- CountryChina
- Language:Chinese
-
Abstract:
Objective Prone position ventilation is one of the most important Methods for the treatment of acute lung injury/acute respiratory distress syndrome (ARDS). Currently, there are fewer researches on prone position ventilation for ARDS caused by acute paraquat poisoning. This article aims to evaluate the value of prone position ventilation in the treatment of moderate and severe ARDS caused by acute paraquat poisoning.Methods Retrospective analysis the clinical data of 43 patients with acute paraquat poisoning complicated with moderate-to-severe ARDS from January 2016 to December 2017 in the Department of Emergency Medicine, Eastern Theater of the Eastern Theater. The patients were divided into two groups according to whether they were in prone position ventilation: experimental group (prone position ventilation, n=13)and control group(no prone position ventilation, n=30). The gender, age, APACHEII score and plasma paraquat concentration of the two groups were statistically analyzed. The oxygenation index, respiratory rate, carbon dioxide partial pressure and mean arterial pressure were compared between the two groups during the first five days after hospitalization. At the same time, the hospital mortality, hospitalization time, mechanical ventilation time were also compared.Results Compared with control group, the oxygenation index (176±13) and carbon dioxide partial pressure \[(33.6±4.3) mmHg\] in the experimental group were significantly increased from the 2nd day to 5th day after hospitalization(P<0.05), but the respiratory rate was significantly decreased(P<0.05). There were no significant differences in hospital mortality, hospitalization time, mechanical ventilation time, and airway accident rate between the two groups (P>0.05).Conclusion Prone position ventilation is safe for patients with moderate to severe ARDS caused by acute paraquat poisoning, which improves oxygenation in these patients but fails to improve prognosis. It provides a theoretical basis for prone position ventilation in the treatment of acute paraquat poisoning complicated with ARDS.
