Mechanisms of deoxycholic acid to promote the initiation and progression of colorectal cancer
10.16571/j.cnki.1008-8199.2018.08.020
- VernacularTitle: 脱氧胆酸促进结直肠癌发生发展的相关机制
- Author:
Yao ZHANG
1
;
Fang-yu WANG
1
Author Information
1. Department of Gastroenterology,Jinling Hospital,Nanjing Medical University/Nanjing General Hospital of Nanjing Military Region,PLA,Nanjing 210002,Jiangsu,China
- Publication Type:Journal Article
- Keywords:
deoxycholic acid;
colorectal cancer;
mechanism research
- From:
Journal of Medical Postgraduates
2018;31(8):878-881
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is a malignant disease of digestive system, with increasing morbidity. As a risk factor of colorectal cancer, high fat diet changes the secretory form of hepatic bile acids and stimulates its secretion. As a result, it increases the concentration of bile acids in the large intestine. Deoxycholic acid promotes the initiation and progression of colorectal cancer through affecting various intracellular signals, modulating expression of multiple genes and influencing the balance of the gut microbiota. The article reviewes the mechanisms of deoxycholic acid to promote the initiation and progression of colorectal cancer.
