Medical big data analysis of the clinical off-label use of proton pump inhibitors
10.3969/j.issn.1006-0111.201909086
- VernacularTitle:质子泵抑制剂临床超适应证使用的医疗大数据分析
- Author:
Xufeng MAO
1
;
Zhangwei YANG
2
Author Information
1. Department of Pharmacy, Changhai Hospital, Navy Medical University, Shanghai 200433, China.
2. Department of Information, Shanghai Fourth People’s Hospital, Shanghai 200081, China.
- Keywords:
proton pump inhibitors;
drug utilization review;
pharmacy administration;
data mining
- From:
Journal of Pharmaceutical Practice
2020;38(2):184-188
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the main causes of the overuse of proton pump inhibitor (PPIs) in domestic hospitalized patients. Methods The electronic medical records of patients in 20 general hospitals from January 1, 2015 to March 31, 2018 were analyzed. The distribution of indications of PPIs, the distribution of different uses of PPIs, the most often diseases of patients using the off-label medications, surgeries and combined medication, etc. were analyzed. Results The number one indication of PPIs was the prevention of NSAIDs-related ulcer, which accounted for 40.9% of the patients and 34.2% of them was off-label users. Among the off-label patients, lansoprazole was the most highly used, which accounted for 48.1%. The most often diseases, surgeries and combined medications of the patients using PPIs were the diseases of esophagus, stomach and duodenum, gallbladder and biliary surgery and mineral supplement. Conclusion The prevention of drug-induced ulcers and the off-label use is the main reasons for the huge amount of PPIs usage. The application of lansoprazole is not standardized; The main causes of the off-label PPIs usage are gastrointestinal discomfort, fasting, surgery and glucocorticoids.
