Preliminary Research on Doxorubicin Loaded Hydrophobic Linear Alkyl Modified Graphene Oxide in Transcatheter Arterial Chemoembolization
- VernacularTitle:阿霉素负载的直链烷基修饰氧化石墨烯经导管动脉化疗栓塞治疗肝癌
- Author:
Ke-yu TANG
1
;
Run LIN
1
;
Yun JIANG
2
;
Nan LI
1
;
Bin CHEN
1
;
Tao ZHANG
2
;
Jian-yong YANG
1
;
Yong-hui HUANG
1
Author Information
1. Department of Interventional Radiology，The First Affiliated Hospital of Sun Yat-Sen University，Guangzhou 510080，China
2. Department of Biomedical Engineering，College of Engineering and Applied Sciences，Nanjing University，Nanjing 210093，China
- Publication Type:Journal Article
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2019;40(3):407-414
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the safety and benefit of doxorubicin loaded hydrophobic linear alkyl modified graphene oxide （DOX@GO- C18） served as vectors in transcatheter arterial chemoembolization （TACE）. 【Methods】 Doxorubicin loaded hydrophobic linear alkyl modified graphene oxide was manufactured and characterized. VX2 liver carcinoma was established in rabbits and the hepatic lesions were treated with TACE using DOX@GO- C18 which was dissolved in lipiodol. Pre- and post- CT scans were performed to evaluate the treatment response. Liver function was assessed via blood samples drawn on day 0（preoperative），1，3，7，and day 14. The animals were sacrificed on day 14 and tissue samples collected to stain for pathology（hematoxylin-eosin staining），lipiodol（oil red O staining）and DOX（fluorescent）.【Results】The dispersion of DOX@GO-C18 in lipiodol was highly stable. Pre-and post-CT scan revealed that the diameter of the VX2 lesions barely varied and enhancements were decreased after the treatment. Target lesions gained stable disease（SD）as the treatment response based on Response Evaluation Criteria in Solid Tumors 1.1（RECIST 1.1）. Histological examination revealed that DOX@GO-C18 was located within the tumor tissue along with the lipiodol. The release of DOX may contribute to the necrosis in tumor.【Conclusions】DOX@GO-C18［CC2］may proved to be a safe and effective vectors in TACE treatment for liver carcinoma.
