Correlations between the Biomechanical Properties of Cornea and Optic Nerve Head in Glaucoma
- VernacularTitle:青光眼角膜生物力学与视盘生物力学的关系
- Author:
Shao-lin DU
1
;
Wen-kai ZHENG
1
;
Xiu-qing DONG
1
;
Ying-dong LUO
1
Author Information
1. Ophthalmic Center，Tungwah Hospital of Sun Yat-sen University，Dongguan 523000，China
- Publication Type:Journal Article
- Keywords:
primary open angle glaucoma, normal tension glaucoma, ocular hypertension, biomechanical properties
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2019;40(6):938-945
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To examine a potential correlation between corneal biomechanical properties with lamina cribrosa thickness.【Methods】Thirty-two patients with POAG，20 with NTG，15 with OHT and 26 healthy controls were included in the cross- sectional study. The parameters of corneal biomechanical properties and lamina cribrosa thickness were compared among POAG，NTG，OHT and healthy subjects by mixed-model analysis of variance（ANOVA）. Spearman′ s coefficient of rank correlation analysis was used to assess the association between parameters of deformation response and clinical factors. 【Results】 The Cronbach′ s α of lamina cribrosa thickness was 0.911，and ICC was more than 0.8. Laminar thickness was thinner in the POAG and NTG groups than in the OHT group and Normal group（P < 0.05）. There were no significant differences between OHT and normal groups（P = 0.653）. Correlation analysis showed that LCT and some important corneal biomechanical properties had significant correlation （P = 0.000）. 【Conclusions】 LCT showed different characteristic in glaucoma，and it may be an important factor for glaucoma progression. LCT and corneal biomechanical properties showed significant correlation ，and corneal biomechanical properties may be used to evaluate the biomechanical properties of optic nerve.
