Effects of Tc17 Cells on Disease Severity and HBV-DNA Elimination in Patients with HBV Related Acute-on-chronic Liver Failure
- VernacularTitle:Tc17细胞对乙肝相关慢加急性肝衰竭病情进展及 乙肝病毒清除的影响
- Author:
Geng-lin ZHANG
1
;
Shi-cheng XU
2
;
Ting ZHANG
2
;
Chao-shuang LIN
1
;
Liang PENG
1
;
Zhi-liang GAO
1
Author Information
1. Department of Infectious Diseases，The Third Affiliated Hospital of Sun Yat-sen University，Guangzhou 510630，China
2. Department of Ultrasound，The Third Affiliated Hospital of Sun Yat-sen University，Guangzhou 510630，China
- Publication Type:Journal Article
- Keywords:
acute-on-chronic liver failure；hepatitis B virus；Tc17 cells
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2019;40(5):739-746
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】To investigate the effects of Tc17 cells on disease severity and elimination of HBV-DNA in
patients with HBV related acute-on-chronic liver failure（HBV-ACLF）.【Methods】Forty-three patients with HBV-
ACLF were enrolled. Twenty patients with chronic hepatitis B（CHB）and 12 healthy subjects（NC）were enrolled as
controls. Flow cytometry was used to detect the expression of peripheral Tc17 cells. HBV-DNA loads were measured，and
the MELD，MELD-Na，CLIF-C ACLF and AARC scores were used to evaluate the disease severity. The effects of Tc17
cells on disease severity and decline of HBV-DNA were analyzed.【Results】Compared with NC group and CHB group，
the expression of Tc17 cells in HBV-ACLF patients was significantly increased（P < 0.001 and P = 0.017）. Correlation
analysis showed that Tc17 cells were positively correlated with AARC score，MELD score and MELD-Na score（r =
0.504，P = 0.001；r = 0.417，P = 0.005 and r = 0.382，P = 0.012），and a correlated trend was found with CLIF-C
ACLF score（r = 0.294，P = 0.055）. And as the disease progressed，the expression of Tc17 cells gradually increased.In addition，Tc17 cells were positively correlated with HBV-DNA levels（r = 0.339，P = 0.026）at baseline，and the
HBV-DNA levels were significantly decreased in patients with higher expression of Tc17 cells than in lower group after 4
weeks of treatment（P < 0.001）. Furthermore，it was found that baseline Tc17 cells and AST levels were associated with
the HBV-DNA decline by multivariate linear regression analysis.【Conclusion】Tc17 cells-mediated inflammatory
response helps clear the HBV-DNA，but excessive inflammatory response may aggravate the disease severity.
