A Single-center Retrospective Analysis of Clinical Epidemiology of Multiple Sclerosis

Jing-qi WANG; Cong LI; Chun-ping CUI; Xiao-nan ZHONG; Ting-ting LU; Yu-ge WANG; Yu YANG; Wei QIU

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A Single-center Retrospective Analysis of Clinical Epidemiology of Multiple Sclerosis

VernacularTitle:一项基于单中心的多发性硬化的临床流行病学回顾性分析
Author: Jing-qi WANG ¹ ; Cong LI ¹ ; Chun-ping CUI ¹ ; Xiao-nan ZHONG ¹ ; Ting-ting LU ¹ ; Yu-ge WANG ¹ ; Yu YANG ¹ ; Wei QIU ¹
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1. Department of Neurology，The Third Affiliated Hospital of Sun Yat-sen University，Guangzhou 510630，China
Publication Type:Journal Article
Keywords: multiple sclerosis；clinical epidemiology；retrospective analysis
From: Journal of Sun Yat-sen University(Medical Sciences) 2019;40(5):731-738
CountryChina
Language:Chinese
Abstract: 【Objective】To summarize current situation of multiple sclerosis in South China and provide reference for MS diagnosis and treatment.【Methods】We selected patients of whom the first diagnosis was MS from 2011 to March 2019，and divided them into Adults group and Pediatrics group according to onset age above or below 14. We analyzed them from epidemiology，symptomatology，accessory examinations and treatment situation.【Results】296 patients were admitted into this research. The ratio of male to female was 1∶1.67. Median onset age was 26. Relapsing-remitting MS accounted for 63.2% of all patients. For initial episode，130 patients had motor symptoms（43.9%），118 patients showed sensory symptoms（39.9%），and 55 patients were accompanied with visual symptoms（18.6%）. Statistical difference exists in sensory symptoms（114 vs. 4，Z = -2.155，P = 0.031）and paroxysmal symptoms（4 vs. 3，Z = -3.610，P = 0.000） of Adults group and Pediatrics group. For following episodes，the total relapsing time was 712，with motor symptoms relapsing 380 times（53.4%），sensory symptoms 265 times（37.2%）and visual symptoms 134 times（18.8%）. Statistical difference existed in motor，sensory，visual，other ocular symptoms and paroxysmal symptoms. Positive rate of Oligoclonal bond was 45.5%. Positive rate of MOG-Ab was 16.7%. For brain MRI，periventricular lesions ≥ 9 accounted for 57.4% of all patients，with cortical & juxtacortical lesions 28.1% and infratentorial lesions 0.3%. Patients who had optic nerve lesions accounted for 63.2%. No statistical difference existed in them. For treatment，drugs they had used previously were glucocorticoid（79.7%），beta Interferon（15.9%）and azathioprine（13.9%）.During the study，drugs they were using were glucocorticoid（15.5%），rituximab（9.1%），azathioprine（8.1%）and teriflunomide（8.1%）.【Conclusions】For gender， age，symptomatology and accessory examinations，results of this research are similar to previous papers about multiple sclerosis in Asian. For treatment，the trend indicates that usage of new disease-modifying drugs goes up.