Clinical Observation of Chinese Medicine Syndrome Differentiation Individual Therapy on Precancerous Lesions of Gastric Cancer
- VernacularTitle:中医辨证个体化疗法治疗胃癌前病变的临床观察
- Author:
Jingqiu LIANG
1
;
Jingyu TAN
1
;
Qi CHEN
1
;
Wei WANG
1
;
Haiyan ZHANG
1
Author Information
1. Chongqing University Cancer Hospital & Chongqing Cancer Institute & Ch ongqing Cancer Hospital，Chongqing 400030，China
- Publication Type:Journal Article
- Keywords:
Chinese medicine syndrome differentiation;
Precancerous lesion of gastric cancer;
Pepsinogen ratio;
Gastrin-17;
Helicobacter pylori
- From:
China Pharmacy
2019;30(24):3433-3436
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE： To provide reference for clinical treatment of precancerous lesions of gastric cancer. METHODS： A total of 685 patients with precancerous lesions of gastric cancer were selected from our hospital during Jan.-Dec. 2018. Totally 455 patients in treatment group received individualized TCM therapy according to syndrome differentiation， 7 days as a course， 4 courses in total； another 230 patients in control group received Folic acid tablets， 5 mg， tid， for 2 months. The changes of pepsinogen ratio （PGⅠ/PGⅡ）， gastrin-17 （G-17） and Helicobacter pylori （Hp）before and after treatment， and the occurrence of ADR were compared between 2 groups. RESULTS： After treatment， total response rate of treatment group was 90.3％， which was significantly higher than 68.6％ of control group. PGⅠ/PGⅡ of treatment group were increased significantly， which was significantly higher than control group； G-17 levels of 2 groups were decreased significantly （P＜0.05）； there was no statistical significance in Hp level between 2 groups before and after treatment （P＞0.05）. There was no statistical significance in the incidence of ADR between 2 groups（P＞0.05）. CONCLUSIONS： Chinese medicine syndrome differentiation individual therapy can significantly delay the development of precancerous lesions of gastric cancer， and has good safety.
