Association of TNF-α gene polymorphisms with
the risk of rheumatoid arthritis in
Han Chinese population from Hunan.
10.11817/j.issn.1672-7347.2015.09.001
- Author:
Fen LI
1
;
Xi XIE
2
;
Jinwei CHEN
2
;
Jiesheng GAO
2
;
Fanggen LU
3
Author Information
1. Department of Rheumatology and Immunology, Second Xiangya Hospital, Central South University, Changsha 410011, China lifen5295255@sohu.com.
2. Department of Rheumatology and Immunology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
3. Department of Gastroenterology,
Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Alleles;
Arthritis, Rheumatoid;
ethnology;
genetics;
Asian Continental Ancestry Group;
Case-Control Studies;
China;
Female;
Genetic Predisposition to Disease;
Genotype;
HLA-DRB1 Chains;
genetics;
Humans;
Male;
Polymorphism, Single Nucleotide;
Tumor Necrosis Factor-alpha;
genetics
- From:
Journal of Central South University(Medical Sciences)
2015;40(9):945-954
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To investigate the association of TNF-α-308 gene polymorphism with the risk of RA in Hunan's Han Chinese population.
METHODS:A total of 112 patients with RA from Han Chinese population in Hunan were recruited, along with 129 healthy controls. TNF-α-308 (rs1800629) gene polymorphisms were analyzed by PCR-RFLP. Serum levels of TNF-α were detected by ELISA.
RESULTS:TNF-α-308 A allele carrier was 3.6% in RA patients and 10.5% in controls (P=0.004); male RA patients displayed noticeably lower rates of TNF-α-308 A allele than that in the male controls (2.8% vs 15.6%, OR=0.179, P=0.007). Patients containing both HLA-DRB1*04 and TNF-α-308 GG genotype showed a significant increase in risk for RA (OR=6.107), no matter they were male (OR=7.273) or female (OR=5.029). Female RA patients with both HLA-DRB1*04 and TNF-α-308 GG showed earlier disease onset and higher TNF-α level.
CONCLUSION:In Han Chinese population from Hunan, susceptibility of RA was increased in patients with TNF-α-308 G allele, especially in the female carrier of genotypes; TNF-α-308 A allele may play a positive role in reduction of RA risk in males.
