Value of single photon emission computed tomography/computerized tomography in the diagnosis of hyperparathyroidism and the comparative study with multiple imaging modality.
10.11817/j.issn.1672-7347.2015.09.012
- Author:
Min ZHAO
1
,
2
;
Xinhui LI
3
;
Jin HUANG
3
;
Xiaoqin YIN
3
Author Information
1. Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha 410008, China manteyzhao@
2. com.
3. Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Hyperparathyroidism;
diagnosis;
diagnostic imaging;
Hyperplasia;
Parathyroid Glands;
diagnostic imaging;
pathology;
Parathyroidectomy;
Radionuclide Imaging;
Retrospective Studies;
Sensitivity and Specificity;
Technetium Tc 99m Sestamibi;
Tomography, Emission-Computed, Single-Photon;
Tomography, X-Ray Computed;
Ultrasonography
- From:
Journal of Central South University(Medical Sciences)
2015;40(9):1016-1022
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the diagnostic value among the single photon emission computed tomography/computerized tomography (SPECT/CT), (99m)Tc-sestamibi (MIBI) planar scintigraphy, ultrasonography (US) and computerized tomography (CT) in diagnosis of patients with hyperparathyroidism (HPT).
METHODS:A total of 59 patients were retrospectively recruited for this study. The patients received parathyroidectomy and were verified by pathological examination. Among them, 31, 28 and 26 patients received SPECT/CT, (99m)Tc-MIBI planar scintigraphy, US and CT, respectively, before the parathyroidectomy. The sensitivity for localization or qualitation was compared between SPECT/CT and (99m)Tc-MIBI planar scintigraphy; the sensitivity, specificity and accuracy were compared among the SPECT/CT, (99m)Tc-MIBI planar scintigraphy, US and CT.
RESULTS:There was no statistical difference in the sensitivity of localization between SPECT/CT and (99m)Tc-MIBI planar scintigraphy (P>0.05); however, the SPECT/CT exhibited more sensitive than the (99m)Tc-MIBI planar scintigraphy in detection of hyperplastic lesions (P<0.05). Among the four imaging modalities, SPECT/CT had advantages over (99m)Tc-MIBI planar scintigraphy in terms of accuracy (P<0.05). In contrast, the sensitivity of CT was not as good as that of SPECT/CT and US (both P<0.05). For the diagnosis of lesions with a diameter more than 1 cm, the sensitivity of SPECT/CT was the best (all P<0.05). However, the sensitivity of US was the best in diagnosis of lesions with a diameter less than 1 cm (all P<0.05).
CONCLUSION:The SPECT/CT is more effective than (99m)Tc-MIBI planar scintigraphy in diagnosis of HPT, especially in diagnosis of hyperplastic lesions. Both of SPECT/CT and US are recommended to localize the target parathyroid lesions of HPT before the parathyroidectomy.
