Influential factors for theraputic effect of steroid on adult primary nephrotic syndrome.
10.11817/j.issn.1672-7347.2015.01.013
- Author:
Chunmei CHEN
1
;
Yuncheng XIA
Author Information
1. Department of Nephrology; Clinical Laboratory, Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Glomerulonephritis, IGA;
drug therapy;
Glomerulosclerosis, Focal Segmental;
drug therapy;
Humans;
Kidney;
physiopathology;
Nephrosis, Lipoid;
drug therapy;
Nephrotic Syndrome;
drug therapy;
Proteinuria;
Retrospective Studies;
Steroids;
therapeutic use;
Urinalysis;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2015;40(1):78-82
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the factors associated with the eff ect of steroid on adult primary nephrotic syndrome.
METHODS:The general information, laboratory examination and renal pathological type of 425 patients with primary nephrotic syndrome were retrospectively analyzed.
RESULTS:Th ere were significant differences in the response to steroid among the pathological types of minimal change disease, focal segmental glomerulosclerosis and IgA nephropathy. Th e patients in the age of 14-24 years old showed the strongest response to steroid (P<0.05). Th e IgA level in the steroid resistance group was lower than that in the non-steroid resistance group (P<0.05). There was no significant difference in urine protein in 24 hour quantitation in the steroid resistance group between pre- and post-treatment (P>0.05), while there was significant difference in urine protein in 24 hour quantitation in the non-steroid resistance group between pre- and post-treatment (P<0.05).
CONCLUSION:Pathological types and ages of the patients are related to the steroid curative effect. The decrease in IgA probably affects the effect of steroid on primary nephrotic syndrome.
