Correlation between children's dental decay and the contents of saliva CCL28 and secretory immunoglobulin A.
10.11817/j.issn.1672-7347.2015.01.016
- Author:
Zhi LIU
1
;
Guoying QUE
;
Jinhuan LI
;
Jinxia DENG
;
Lulu LI
;
Tingting LIU
;
Da SU
Author Information
1. Cener of Oral Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Chemokines, CC;
analysis;
Child, Preschool;
Dental Caries;
pathology;
Enzyme-Linked Immunosorbent Assay;
Humans;
Immunoglobulin A, Secretory;
analysis;
Saliva;
chemistry
- From:
Journal of Central South University(Medical Sciences)
2015;40(1):102-106
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the association of the dental decay of children with the contents of chemokine CCL28 and secretory immunoglobulin A (sIgA) in saliva.
METHODS:A total of 108 children in 2 kindergartens of Changsha, with age from 3 to 5 years old, were enrolled for this study. The saliva was collected from these children when they were in the examination of mouth. Th e children were divided into 3 groups: A non-caries group [dynamical mean-field theory (DMFT)=0], a low caries group (DMFT=1-4) and a high caries group (DMFT ≥ 5). Th e contents of CCL28 and sIgA were measured by ELISA.
RESULTS:The contents of CCL28 and sIgA in saliva were (121.22 ± 32.63) pg/mL and (16.49 ± 8.02) μg/mL, respectively. A positive linear correlation was found between the CCL28 content and sIgA content in saliva (r=0.734). Th e CCL28 and sIgA contents in saliva were positively correlated with the degree of dental caries in children (P<0.05).
CONCLUSION:The dental decay of children leads to the secretion of chemokine CCL28, which promotes the secretion of sIgA in saliva.
