Brain structure analysis for patients with antisocial personality disorder by MRI.
10.11817/j.issn.1672-7347.2015.02.002
- Author:
Weixiong JIANG
1
;
Jian LIAO
;
Huasheng LIU
;
Renzhi HUANG
;
Yongfan LI
;
Wei WANG
Author Information
1. Department of Radiology, Th ird Xiangya Hospital, Central South University, Changsha 410013; Department of Information Science and Engineering, Hunan First Normal University, Changsha 410205, China.
- Publication Type:Journal Article
- MeSH:
Anisotropy;
Antisocial Personality Disorder;
diagnosis;
Brain;
anatomy & histology;
Case-Control Studies;
Diffusion Tensor Imaging;
Humans;
Magnetic Resonance Imaging
- From:
Journal of Central South University(Medical Sciences)
2015;40(2):123-128
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the structural abnormalities of brain in patients with antisocial personality disorder (ASPD) but without alcoholism and drug abuse.
METHODS:Volunteers from Hunan Reformatory (n=36) and the matched healthy subjects (n=26) were examined by high-spatial resolution magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). Voxel-based morphometry and fractional anisotropy (FA) maps were generated for each subject to reveal structural abnormalities in patients with ASPD.
RESULTS:Compared with the healthy controls, ASPD patients showed significantly higher gray matter volumes in the inferior parietal lobule (P≤0.001, uncorrected), white matter volumes in the precuneus (P≤0.001, uncorrected), FA in the left lingual gyrus, bilateral precuneus, right superior frontal gyrus and right middle temporal gyrus (P≤0.01, uncorrected).
CONCLUSION:Our results revealed the abnormal neuroanatomical features in ASPD patients, which might be related to the external behavioral traits in ASPD patients.
