Association of TNFRSF1B +676 gene polymorphism with the risk of rheumatoid arthritis in Han Chinese population in Hunan.
10.11817/j.issn.1672-7347.2016.09.002
- Author:
Xi XIE
1
;
Fen LI
1
;
Jinwei CHEN
1
;
Jiesheng GAO
1
;
Fanggen LU
2
Author Information
1. Department of Rheumatology and Immunology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
2. Department of Gastroenterology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Alleles;
Arthritis, Rheumatoid;
ethnology;
genetics;
Asian Continental Ancestry Group;
Female;
Gene Frequency;
Genetic Association Studies;
Genetic Predisposition to Disease;
Genotype;
Humans;
Male;
Polymorphism, Genetic;
genetics;
Polymorphism, Single Nucleotide;
Receptors, Tumor Necrosis Factor, Type II;
blood;
genetics;
Risk Factors
- From:
Journal of Central South University(Medical Sciences)
2016;41(9):891-897
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To study the association of TNFRSF1B +676 gene (rs1061622) polymorphism with the risk of rheumatoid arthritis (RA ) in Han Chinese population of Hunan.
METHODS:A total of 112 patients with RA from Han Chinese population in Hunan were recruited, along with 129 healthy controls. TNFRSF1B +676 (rs1061622) gene polymorphisms were examined by PCR-RFLP. Serum levels of soluble TNFR II were analyzed by ELISA.
RESULTS:RA patients displayed a similar TNFRSF1B +676 genotype to controls (GG/TG/TT: 5/62/45 vs 9/56/64, P=0.167), but signifi cant diff erence was found between female RA patients and female controls (GG/TG/TT: 3/49/24 vs 8/28/48, P<0.001). No significant difference was found in the frequency of TNFRSF1B +676 T or G allele between RA patients and controls (P>0.05). RA patients showed a signifi cantly higher level of serum soluble tumor necrosis factor receptor II (sTNFR II) than controls [(7.83±2.61) ng/mL vs (4.32±1.67) ng/mL, P<0.001], but there was no diff erence among the three genotypes (P>0.05). No association was found between TNFRSF1B+676 gene polymorphism and RA clinical characteristics.
CONCLUSION:In Han Chinese population of Hunan province, TNFRSF1B+676 gene polymorphisms are not associated with the genetic risk of RA .
