Effect of stellate ganglion block on reconstruction of the left ventricle in spontaneously hypertensive rats.
10.3969/j.issn.1672-7347.2013.01.008
- Author:
Yongquan CHEN
1
,
2
;
Guangxiang HU
;
Qun FU
;
Xiaoju JIN
Author Information
1. Department of Anesthesiology, Affiliated Hospital, Wannan Medical College, Wuhu Anhui 241001, China. chenyq263@
2. com
- Publication Type:Journal Article
- MeSH:
Animals;
Autonomic Nerve Block;
Hypertension;
physiopathology;
therapy;
Male;
Rats;
Rats, Inbred SHR;
Stellate Ganglion;
Ventricular Remodeling;
physiology
- From:
Journal of Central South University(Medical Sciences)
2013;38(1):43-47
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the effect of stellate ganglion block on reconstruction of the left ventricle in spontaneously hypertensive rats (SHRs).
METHODS:Thirty-two 10-week-old male SHRs were randomly assigned into 4 groups: a left stellate ganglion block group (group LS), a right stellate ganglion block group (group RS), a captopril group (group D) and a control group (group C). The arterial systolic blood pressure (SBP) was measured by ALC-NIBP measuring system. After 10 weeks, we observed the left ventricular mass index (LVMI), myocardial pathologic changes, and detected the endothelin (ET-1) and endothelial nitric oxide synthase (eNOS) level in the left ventricle by radioimmunoassay and the collagen protein level in the left ventricle by immunohistochemical method.
RESULTS:Compared with group LS and group C, the LVMI in group RS was lowered most notably (P<0.05) and pathological changes were improved obviously. The expression of eNOS in group RS was significantly increased and ET-1 significantly decreased (P<0.05) compared with that in group C and group LS. The expression of type I collagen fibers in group RS was significantly lower and type III collagen fibers significantly higher (P<0.05) when compared with that in group C and LS.
CONCLUSION:Right stellate ganglion block can not only decrease the arterial pressure but also reverse the reconstruction of the left ventricle.
