Visfatin level after laparoscopic Roux-en-Y gastric bypass surgery in patients with Type 2 diabetes.
10.3969/j.issn.1672-7347.2013.03.007
- Author:
Yiqun LIU
1
,
2
;
Jing XIONG
;
Honghui HE
;
Shaihong ZHU
;
Zhaohui MO
Author Information
1. Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China. easd04mzh@
2. com
- Publication Type:Journal Article
- MeSH:
Diabetes Mellitus, Type 2;
blood;
surgery;
Female;
Gastric Bypass;
Humans;
Insulin Resistance;
Laparoscopy;
Male;
Middle Aged;
Nicotinamide Phosphoribosyltransferase;
blood;
Postoperative Period
- From:
Journal of Central South University(Medical Sciences)
2013;38(3):258-261
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the change in serum visfatin level after laparoscopic Roux-en-Y gastric bypass surgery in patients with Type 2 diabetes mellitus (T2DM) and to explore the relationship between visfatin insulin resistance and diabetes.
METHODS:Thirty-three patients with Type 2 diabetes were studied before and after the gastric bypass surgery. The level of fasting serum visfatin was measured by enzyme-linked immunosorbent assay. Fasting plasma glucose (FPG), glycated hemoglobin (HbA1c) and fasting insulin (FINS) were measured before and after the gastric bypass surgery.
RESULTS:Compared with before the operation, the indicators of HbA1c, FINS, and insulin resistance index (HOMA-IR) were decreased after the laparoscopic Roux-en-Y gastric bypass surgery. The body mass index (BMI) [(24.53 ± 0.62) kg/m² vs (26.71 ± 0.69) kg/m2] was decreased, with significant difference (P<0.001). The serum visfatin level [(9.79 ± 0.64) ng/mL] was significantly lower than before the operation [(38.24 ± 5.32) ng/mL], with significant difference (P<0.001).
CONCLUSION:Serum level of visfatin is decreased in T2DM patients who undergo gastric bypass surgry, reflecting an improvement in insulin resistance and diabetes.
