Serum vitamin D levels in postmenopausal women with type 2 diabetes mellitus.
10.3969/j.issn.1672-7347.2013.10.012
- Author:
Lingjia LIU
1
;
Ying HU
;
Juanxia CHUI
;
Yuhang HU
;
Bichen WU
;
Xin SU
Author Information
1. Department of Endocrinology, Second Xiangya Hospital, Central South University; Diabetes Center, Central South University; Institute of Metabolism and Endocrinology, Central South University; Key Laboratory of Diabetes Immunology, Ministry of Education, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Body Mass Index;
Calcitriol;
blood;
Case-Control Studies;
Diabetes Mellitus, Type 2;
blood;
Female;
Humans;
Postmenopause;
Prevalence;
Vitamin D Deficiency
- From:
Journal of Central South University(Medical Sciences)
2013;38(10):1051-1056
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the correlation between serum vitamin D levels and index of glucose and lipid metabolism in postmenopausal women with type 2 diabetes mellitus (T2DM).
METHODS:A total of 44 postmenopausal women with T2DM and 41 healthy postmenopausal women were matched with age, body mass index and menopausal duration. The serum vitamin D was detected by enzyme-linked immuno-sorbent assay (ELISA).
RESULTS:Compared with the control group, the level of 25(OH)D3 in postmenopausal women with T2DM was lower, with no statistical significance. Multiple regression analysis revealed that only BMI(bj'=-0.372, P<0.05) was independently related to 25(OH)D3 with statistical significance. The percentages of 25(OH)D3 deficiency in all subjects in the control group and in the T2DM group were 84.7%, 80.5%, and 88.6%, respectively. The 25(OH)D3 deficiency in the T2DM group was more prevalent than that in the control group, with no statistical difference (P=0.372). The binary logistic regression analysis showed the serum 25(OH)D3 level was not related to the risk of diabetes.
CONCLUSION:Compared with the control group, a lower 25(OH)D3 level and a higher rate of 25(OH)D3 deficiency is found in T2DM subjects. When rectified by BMI, these is no significant difference. In postmenopausal women, hypovitaminosis D is associated with obesity and dyslipidemia, but not with the risk of T2DM.
