Correlation between ABCC11 gene single nucleotide polymorphism and the incidence of axillary osmidrosis in Chinese Han population.
10.3969/j.issn.1672-7347.2013.11.010
- Author:
Yang SUN
1
;
Jianhong LONG
;
Yongjie WANG
Author Information
1. Department of Plastics and Cosmetic Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
ATP-Binding Cassette Transporters;
genetics;
Alleles;
Asian Continental Ancestry Group;
Axilla;
Gene Frequency;
Genotype;
Humans;
Incidence;
Polymorphism, Single Nucleotide;
Sweat Gland Diseases;
genetics
- From:
Journal of Central South University(Medical Sciences)
2013;38(11):1141-1145
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the relationship between ABCC11 gene single nucleotide polymorphism (SNP) and the incidence of axillary osmidrosis in Chinese Han population.
METHODS:The genotype of ABCC11 gene SNP at rs17822931 in 40 patients with axillary osmidrosis and 5 normal Han people was detected and analyzed by high resolution melt and gene sequencing.
RESULTS:The detection of the genotype of ABCC11 gene SNP at rs17822931 showed that: 37 of the 40 patients were GA genotype and the other 3 were GG genotype, while the 5 normal subjects were AA genotype.
CONCLUSION:SNP in ABCC11 is the genetic cause of axillary osmidrosis. GG or GA leads to axillary osmidrosis, while AA allele presents the absence of axillary osmidrosis.
