(1)H-magnetic resonance spectroscopy on bilateral thalamus of patients with secondarily generalized tonic-clonic seizures.
10.3969/j.issn.1672-7347.2012.11.012
- Author:
Mingyue WANG
1
;
Shuyu LI
;
Gaofeng ZHOU
;
Weihua LIAO
;
Guoliang LI
;
Bo XIAO
Author Information
1. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aspartic Acid;
analogs & derivatives;
analysis;
Brain Chemistry;
Case-Control Studies;
Choline;
analysis;
Energy Metabolism;
physiology;
Epilepsy, Generalized;
metabolism;
physiopathology;
Epilepsy, Tonic-Clonic;
metabolism;
physiopathology;
Female;
Humans;
Magnetic Resonance Spectroscopy;
methods;
Male;
Middle Aged;
Thalamus;
metabolism;
physiopathology;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2012;37(11):1147-1151
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To examine the changes of metabolites in the bilateral thalamus of patients with secondarily generalized tonic-clonic seizure (SGTCS) and to explore the mechanism of SGTCS.
METHODS:Thirty patients with SGTCS (epilepsy group) and 30 matched healthy controls (control group) were examined by 1H-magnetic resonance spectroscopy (1H-MRS). The levels of N-acetyl aspartate (NAA), choline-containing compounds (Cho), creatine phosphocreatine (Cr-PCr), and myo-inositol (mI) of the bilateral thalamus were measured in both the epilepsy group and the control group. The ratios of NAA/Cr-PCr, NAA/(Cr-PCr+Cho), Cho/Cr-PCr and mI/Cr-PCr were compared and analyzed in the 2 groups.
RESULTS:The ratios of NAA/Cr-PCr, and NAA/(Cr-PCr+Cho)(1.7074 ± 0.2214; 0.9333 ± 0.2173) in the left thalamus in the epilepsy group were significantly lower than those in the control group(1.8834 ±0.2093; 1.1243 ±0.2447)(P<0.05). The ratios of NAA/Cr-PCr, and NAA/(Cr- PCr+Cho) (1.7472 ±0.2439; 0.9165 ±0.2462) in the right thalamus in the epilepsy group were also significantly lower than those in the control group(1.8925 ± 0.2004; 1.0941 ± 0.2372)(P<0.05). There were no significant differences in the ratios of NAA/Cr-PCr, NAA/(Cr-PCr+Cho), Cho/Cr- PCr, and mI/Cr-PCr between the bilateral thalamis in the epilepsy group (P>0.05).
CONCLUSION:There is neuronal dysfunction in the bilateral thalamus in the epilepsy group. Abnormal changes of the bilateral thalamus are involved in the mechanism of SGTCS.
