Correlation between expression of HIF-2α and OCT-4 and prognosis of NSCLC.
10.3969/j.issn.1672-7347.2011.09.007
- Author:
Linfang WEI
1
;
Xianling LIU
;
Chunhong HU
Author Information
1. Department of Oncology, Second Xiangya Hospital, Central South University, Changsha, China.
- Publication Type:Journal Article
- MeSH:
Basic Helix-Loop-Helix Transcription Factors;
metabolism;
Biomarkers, Tumor;
metabolism;
Carcinoma, Non-Small-Cell Lung;
diagnosis;
metabolism;
Female;
Humans;
Lung Neoplasms;
diagnosis;
metabolism;
Male;
Octamer Transcription Factor-3;
metabolism;
Prognosis
- From:
Journal of Central South University(Medical Sciences)
2011;36(9):854-858
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression and significance of hypoxia inducible factor-2α (HIF-2α) and transcription factor OCT-4 in non-small cell lung cancer (NSCLC), and evaluate their roles in the prognosis of NSCLC.
METHODS:Tissues from 51 cases of NSCLC were collected and immunohistochemistry (SP method) was used to detect the expression of HIF-2α and OCT-4 proteins. The correlation between the protein expression and the prognosis of NSCLC was analyzed.
RESULTS:The positive rates of HIF-2α and OCT-4 expression in the NSCLC were 52.9% and 72.5%, respectively. There was significant relation between the expression of HIF-2α and OCT-4 (r=0.514,P<0.01). High expression of them revealed poor prognosis for NSCLC patients characterized with a bad overall survival(P<0.05).
CONCLUSION:There is a negative corelation between the expression of HIF-2α and OCT-4 and the prognosis of NSCLC. Combined examination of HIF-2α and OCT-4 expression might be an important biomarker for NSCLC prognosis.
