Dentification ability of inbred strain mice tooth germs homologically transplanted into oral submucosa.
10.3969/j.issn.1672-7347.2010.05.019
- Author:
Heng LI
1
;
Guoying QUE
;
Lei ZHANG
Author Information
1. Department of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Animals, Newborn;
Dentinogenesis;
physiology;
Male;
Mice;
Mice, Inbred BALB C;
Molar;
transplantation;
Mouth Mucosa;
surgery;
Tissue Engineering;
Tooth Germ;
transplantation
- From:
Journal of Central South University(Medical Sciences)
2010;35(5):524-528
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a suitable environment for the bioengineered teeth in vivo by observing the dentification ability of BALB/C mice tooth germs homologically implanted into the oral submucosa.
METHODS:The first molar tooth germs of BALB/C mice 4 days after birth were transplanted into the oral submucosa of BALB/C male mice, and then recycled for regular histological observation after 1, 2, 3, and 6 week transplantation.
RESULTS:The tooth germs in the oral submucosa grew well with continuing developing enamelum and pulpodentinal complex, and the dentinal tubules were clear.
CONCLUSION:The environment of the BALB/C male mice oral submucosa is favorable for the growth of tooth germs in inbred strain BALB/C mice, and it can provide a new environment for the development of bioengineered teeth in vivo.
