Primary study of resting state functional magnetic resonance imaging in early onset schizophrenia using ReHo.
10.3969/j.issn.1672-7347.2010.09.008
- Author:
Shao'ai JIANG
1
;
Bing ZHOU
;
Yanhui LIAO
;
Weiqing LIU
;
Changlian TAN
;
Xiaogang CHEN
;
Jinsong TANG
Author Information
1. Institute of Mental Health, Second Xiangya Hospital, Central South University, Changsha, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Brain;
physiopathology;
Case-Control Studies;
Child;
Female;
Humans;
Magnetic Resonance Imaging;
methods;
Male;
Prefrontal Cortex;
physiopathology;
Schizophrenia;
physiopathology;
Time Factors;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2010;35(9):947-951
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the regional homogeneity of resting state brain activity in early onset schizophrenia using functional magnetic resonance imaging.
METHODS:Schizophrenia or schizophreniform disorder was diagnosed according to DSM-IV-TR (diagnostic and statistical manual of mental disorders, fourth edition, text revision). A total of 18 adolescents with early-onset schizophrenia (EOS; onset of psychotic symptoms by age 18) and 18 age- and gender-matched healthy volunteers were tested in a resting-state fMRI scan. Regional homogeneity approach was used to analyze the functional imaging data,and statistical parametric mapping 5 (SPM5)was used to perform t-test in ReHo maps between the patients and controls.
RESULTS:In comparison with the controls, the early-onset patients showed significantly decreased regional homogeneity in bilateral medial prefrontal cortex(P<0.001,uncorrected; voxel>20), but no brain regions showed significantly increased regional homogeneity in the patients.
CONCLUSION:Regional homogeneity of resting state brain activities in EOS was decreased in bilateral medial prefrontal cortex. These abnormal changes may be involved in the psychopathology of schizophrenia.
