Clinical characteristics and operative effect of hippocampus lesions.
10.3969/j.issn.1672-7347.2010.12.014
- Author:
Xingjun JIANG
1
;
Zhiquan YANG
;
Xianrui YUAN
;
Jun WU
;
Dun YUAN
;
Xuejun LI
;
Yonghong HOU
Author Information
1. Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Brain Neoplasms;
surgery;
Child;
Child, Preschool;
Epilepsy;
surgery;
Female;
Glioma;
surgery;
Hippocampus;
pathology;
Humans;
Male;
Middle Aged;
Retrospective Studies;
Sclerosis;
surgery;
Temporal Lobe;
surgery;
Treatment Outcome;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2010;35(12):1282-1287
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the clinical characteristics and operative effect of hippocampus lesions.
METHODS:We retrospectively analyzed the clinical characteristics and operative outcome of 44 patients with hippocampus lesions between August 2005 and April 2010.
RESULTS:Seizure attack was the initial symptom among 40 of the 44 patients. Pathological examinations revealed 18 gliomas, 9 cavernous malformations, 12 hippocampus sclerosis, 2 focal cortical dysplasia, 1 atypical hyperplasia, 1 injury glial scar, and 1 encephalomalacia. Thirteen patients received anterior medial temporal lobectomy and the other 31 received lesionectomy or selective amygdalohippocampectomy via transsylvian approach. An average of 15.7 month follow-up was accomplished in 37 patients. Postoperative epileptic outcomes were evaluated according to Engel classification: Grade I 73.0%(27/37), Grade II 13.5%(5/37), Grade III 10.8%(4/37) and Grade IV 2.7%(1/37). No perioperative death occurred. One patient experienced hemiplegia but recovered 8 months after the operation. Noticeable postoperative visual field deficit was left in 2 patients. Two patients with glioma died of remote tumor recurrence during follow-up.
CONCLUSION:Seizure attack is a major complaint of hippocampus lesions. Satisfactory seizure and tumor control may be achieved through anterior medial temporal lobectomy or selective amygdalohippocampectomy with lesionectomy.
