Efficacy of 4 kinds of triple strategy for Helicobacter pylori eradication.
- Author:
Yu LI
1
;
Xiao-Yan WANG
;
Shou-Rong SHEN
Author Information
1. Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
2-Pyridinylmethylsulfinylbenzimidazoles;
administration & dosage;
Adolescent;
Adult;
Aged;
Anti-Bacterial Agents;
administration & dosage;
Anti-Ulcer Agents;
administration & dosage;
Clarithromycin;
administration & dosage;
Drug Therapy, Combination;
Duodenal Ulcer;
microbiology;
Female;
Furazolidone;
administration & dosage;
Helicobacter Infections;
drug therapy;
Helicobacter pylori;
Humans;
Male;
Middle Aged;
Rabeprazole;
Stomach Ulcer;
microbiology;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2008;33(12):1129-1131
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the efficacy and safety of 4 kinds of triple strategy of Helicobacter pylori (Hp) eradication.
METHODS:A total of 307 patients who suffered from Hp infection, confirmed by rapid urease test (RUT) and 14C-urea breath test (UBT),were randomly divided into 4 groups. Each group had 80, 76, 77, and 74 patients respectively. Group A was treated with rabeprazole, clarithromycin, and furazolidone (RCF); Group B with ranitidine bismuth citrate, clarithromycin, and furazolidone (BCF); Group C with rabeprazole, amoxicillin, and furazolidone (RAF); while Group D with ranitidine bismuth citrate, amoxicillin, and furazolidone (BAF). Hp was detected by RUT and UBT at 4 weeks after later treatment.
RESULTS:Hp eradication rates of group A,B,C, and D were 90.0%,67.1%,62.3%,and 45.9%,respectively. The difference between Group A and Group B, Group A and Group C was significant (P<0.05). Eradication rate of Group B and C was higher than that of Group D (P<0.05). There was no statistical difference between the eradication rate of Group B and C, and among the side effects of the 4 groups.
CONCLUSION:The strategy of RCF was the best among the 4 triple strategy of Hp eradication, which can be used clinically.
