Experimental study of portal hemodynamics after microcapsule transplantation by intraportal and transarterial approach.
- Author:
Feng GAO
1
;
Wei WANG
;
Rui-zhen LI
;
Sheng LIU
;
Ping ZHOU
;
Wei ZHENG
;
Shao-dong AI
Author Information
1. Center of Cell Transplantation and Gene Therapy, Third Xiangya Hospital, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Alginates;
Animals;
Capsules;
Dogs;
Glucuronic Acid;
Hemodynamics;
Hepatic Artery;
Hexuronic Acids;
Infusions, Intra-Arterial;
methods;
Infusions, Intravenous;
methods;
Islets of Langerhans Transplantation;
methods;
Male;
Portal Vein;
diagnostic imaging;
physiopathology;
Random Allocation;
Ultrasonography, Doppler, Color
- From:
Journal of Central South University(Medical Sciences)
2008;33(1):38-42
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the changes of portal hemodynamics after microcapsule transplantation by intraportal and transarterial approach with color doppler sonography.
METHODS:Thirty male dogs were divided into 2 groups randomly: Group PV (microcapsules implanted into the portal vein) and Group HA (microcapsules implanted into the hepatic artery). Both groups were divided into 3 subgroups(PV1, PV2, and PV3; HA1, HA2, and HA3) according to the number of implanted microcapsules (8,000/kg, 16,000/kg, and 32,000/kg). The internal diameter and flow velocity of the portal vein were measured with color doppler sonography before the transplantation,within 24 hours and 1, 2, and 4 weeks after microcapsule transplantation.
RESULTS:The flow velocity of the portal vein in Group PV1 and PV2 within 24 hours increased significantly (P<0.05); The meanwhile the internal diameters did not change significantly (P> 0.05). The flow velocity of the portal vein in Group PV3 within 24 hours decreased significantly (P<0.05), but the internal diameter increased significantly (P<0.05). Portal hemodynamics of different transarterial subgroups did not change significantly (P> 0.05). The level of ALT in Group PV and Group HA all increased significantly (P<0.05). And when the numbers of microcapsule transplantation were same, the level of ALT in subgroup PV were significantly higher than that in subgroup HA (P<0.05).
CONCLUSION:Microcapsule transplantation by transarterial approach is safer than by intraportal way, and the hepatic artery can contain more microcapsule than the portal vein.
