Establishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria.
- Author:
Jung Yeon PARK
1
;
Chulmin PARK
;
Hye Sun CHUN
;
Ji Hyun BYUN
;
Sung Yeon CHO
;
Dong Gun LEE
Author Information
- Publication Type:Brief Communication
- Keywords: Laboratory animal models; Peritonitis; Drug resistance, Multidrug resistance; Gram-negative bacteria
- MeSH: Acinetobacter; Animals; Bacteria; Bacterial Infections; Communicable Diseases; Escherichia coli; Female; Gastric Mucins*; Gram-Negative Bacteria*; Humans; Klebsiella pneumoniae; Korea; Methods; Mice; Models, Animal; Peritonitis*; Pseudomonas aeruginosa
- From:Infection and Chemotherapy 2017;49(1):57-61
- CountryRepublic of Korea
- Language:English
- Abstract: Animal models are essential to studies of infectious diseases. The use of mice to test bacterial infection has been extensively reported. However, methods applied to clinical isolates, particularly for carbapenem-resistant bacteria, must be tailored according to the infection models and bacteria used. In this study, we infected 6-week-old female BALB/c mice intraperitoneally with different strains of resistant bacteria plus 3% hog gastric mucin. This method was found to be efficient and readily applicable for investigation of carbapenem-resisant Gram-negative pathogens (e.g., Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii) detected in Korea.
