Changes of prethrombotic state indexes in patients with malignant cancer.
- Author:
Shajidan ABUDOUREYIMU
1
;
Hong-liang ZHANG
;
Renaguli AIZEZI
;
Wei JIN
;
Halmurat UPUR
Author Information
1. Department of Immunology, Xinjiang Medical University, Xinjiang Autonomous Region, Urumqi 830054, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Blood Coagulation;
Blood Platelets;
metabolism;
Case-Control Studies;
Endothelin-1;
blood;
Female;
Fibrinogen;
metabolism;
Humans;
Male;
Middle Aged;
Neoplasms;
blood;
P-Selectin;
metabolism;
Partial Thromboplastin Time;
Plasminogen Activator Inhibitor 1;
blood;
Prothrombin Time;
Thrombin Time;
Tissue Plasminogen Activator;
blood
- From:
Journal of Central South University(Medical Sciences)
2007;32(6):973-977
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the changes and significance of prethrombotic state indexes in patients with malignant cancer.
METHODS:The expression of CD62p on platelets, level of plasma tissue plasminogen activator (t-PA), level of serum endothelin (ET-1), activated partial thromboplastin time (APTT), fibrinogen ( FIB), prothrombin time (PT), and thrombin time (TT) were examined by flow cytometer, enzyme-linked immunosorbent assay, radioimmunoassay method, and auto coagulometer.
RESULTS:The average expression of CD62P, level of plasma FIB and serum ET-1 in the tumor group increased compared with those in the control group (P<0.05); the level of t-PA in the tumor group decreased compared with that in the control group (P<0.05). APTT and PT were significantly shortened in the tumor group (P<0.05). There was no significant changes of TT in 2 groups (P>0.05).
CONCLUSION:The platelet is activated, the thrombin activity increases, and the fibrinolytic function declines in patients with malignant cancer; there is an obvious prethrombotic state in patients with malignant cancer.
