Association of CACNA1C gene genetic polymorphism with the susceptibility as well as prognosis for chronic spontaneous urticaria.
10.11817/j.issn.1672-7347.2018.09.001
- Author:
Jinjie YAN
1
;
Qinglin LI
1
;
Yuxue LUO
1
;
Siyu YAN
2
;
Yijing HE
2
;
Xiang CHEN
2
Author Information
1. Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008; 2012 Grade Five Years of Clinical Medicine, Xiangya School of Medicine, Central South University, Changsha 410078, China.
2. Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008; Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Calcium Channels, L-Type;
genetics;
Chronic Disease;
Genetic Predisposition to Disease;
Histamine H1 Antagonists, Non-Sedating;
therapeutic use;
Humans;
Loratadine;
analogs & derivatives;
therapeutic use;
Polymorphism, Single Nucleotide;
Prognosis;
Retrospective Studies;
Urticaria;
drug therapy;
genetics
- From:
Journal of Central South University(Medical Sciences)
2018;43(9):929-936
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the relationship between single nucleotide polymorphisms (SNPs) of CACNA1C (SNPs rs58619945, rs7316246 and rs216008) and susceptibility of chronic spontaneous urticaria (CSU) as well as the curative effect of non-sedating antihistamine drugs.
Methods: Peripheral blood were extracted from 191 CSU patients to collect DNA. Urticaria Activity Score 7 (UAS7) and Dermatology Life Quality Index (DLQI) changes were collected from these patients with different non-sedating antihistamine drugs. PubMed retrieval system was used to select the 3 SNPs (rs58619945, rs7316246 and rs216008) of CACNA1C. Susceptibility of CSU and curative effect of non-sedating antihistamine drugs (desloratadine, mizolastine, fisofenadine) in 189 CSU patients and 105 controls with different SNPs were compared with Chi-squared test. Data of 105 southern Chinese controls were extracted from the 1 000 genome database.
Results: Frequency of rs58619945 G allele in the CSU patients was significantly higher than that in the controls [OR(95%CI)=0.660(0.470-0.925), P=0.016]. However, there was no significant differences in rs7316246 and rs216008 between the CSU patients and the controls. Meanwhile there was no significant difference in general curative effect of the 3 drugs in the 3 SNPs (rs58619945: OR=0.843, P=0.454; rs7316246: OR=2.103, P=0.102; rs216008: OR=0.237, P=0.363). There was significant difference in different alleles of rs216008 in the patients administered by desloratadine [OR(95%CI)=0.480(0.247-0.933), P=0.029]. No difference was shown in the 3 SNPs in patients administered by mizolastine.
Conclusion: The rs58619945 A/G might be related to susceptibility of CSU, and the rs216008 mutation might affect drug response of desloratadine.
