Research progress in AMP-activated protein kinase and sepsis-induced cardiac dysfunction.
10.11817/j.issn.1672-7347.2018.12.013
- Author:
Yamin LI
1
;
Jianfeng QIAO
1
;
Wenxuan ZHANG
2
;
Zhenyu PENG
2
Author Information
1. Department of Nursing, Second Xiangya Hospital, Central South University, Changsha 410011; Xiangya Nursing School, Central South University, Changsha 410013, China.
2. Department of Emergency Medicine, Second Xiangya Hospital; Central South University, Changsha 410011; Emergency Medicine and Diffi cult Diseases Institute, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
AMP-Activated Protein Kinases;
metabolism;
Apoptosis;
Autophagy;
Heart Diseases;
enzymology;
etiology;
Humans;
Sepsis;
complications
- From:
Journal of Central South University(Medical Sciences)
2018;43(12):1364-1368
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis-induced cardiac dysfunction is a serious complication of sepsis with no effective treatment. AMP-activated protein kinase (AMPK) is a regulator for energy metabolism in cells and plays a key role in the energy balance. Recent studies have shown that AMPK exerted a protective effect on sepsis-induced cardiac dysfunction, which was related to the regulation of inflammation, endothelial cells injury, energy metabolism, myocardial cells apoptosis and autophagy. Therefore, AMPK is a therapeutic target for sepsis-induced cardiac dysfunction.
