TDP-43 in male infertility: Progress in studies.
- Author:
Peng CHENG
1
;
Xian-Sheng ZHANG
1
Author Information
1. Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
- Publication Type:Journal Article
- MeSH:
DNA-Binding Proteins;
metabolism;
Gene Expression Regulation;
Humans;
Infertility, Male;
etiology;
metabolism;
Male;
RNA-Binding Proteins;
metabolism;
Spermatozoa;
metabolism;
Testis;
metabolism
- From:
National Journal of Andrology
2017;23(10):942-945
- CountryChina
- Language:Chinese
-
Abstract:
Approximately 10－15% of couples worldwide fail to achieve a pregnancy within a year after marriage. Male factors account for about 50% of the causes of infertility and the causes of male infertility are complicated and varied, and many of them are not yet clear. In recent years, the role of RNA-binding proteins in male infertility has attracted much attention. The transactive response DNA-binding protein of 43 kDa (TDP-43) is involved in gene regulation in the testis, and its abnormal expression may affect male reproduction and lead to male infertility. The distribution and expression of TDP-43 vary in normal and abnormal spermatozoa and may be a marker of male infertility. This article presents an overview on the structure of TDP-43 and its role in male infertility.
