A new phenylpropanoid glycoside from the fruits of Illicium simonsii.
10.1016/S1875-5364(12)60004-1
- Author:
Dan-Dan WEI
1
;
Jun-Song WANG
;
Yao ZHANG
;
Ling-Yi KONG
Author Information
1. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
- Publication Type:Journal Article
- MeSH:
Carcinoma, Non-Small-Cell Lung;
drug therapy;
Fruit;
chemistry;
Humans;
Illicium;
chemistry;
Lactones;
isolation & purification;
Monosaccharides;
isolation & purification;
Plant Extracts;
chemistry;
Sesquiterpenes;
isolation & purification
- From:
Chinese Journal of Natural Medicines (English Ed.)
2012;10(1):20-23
- CountryChina
- Language:English
-
Abstract:
AIM:To study the constituents and bioactivity of Illicium simonsii.
METHODS:The extracts of the fruits of Illicium simonsii were submitted to a combination of chromatographic materials, silica gel, ODS column chromatography and finally preparative HPLC to obtain eight compounds which were further evaluated for their cytotoxicity by MTT method.
RESULTS:A new phenylpropanoid glycolside, 2, 4-dihydroxy-allylbenzene-2-O-β-D-glucopyranoside (1), together with seven characteristic sesquiterpene lactones, oligandrumin B (2), oligandrumin D (3), anisatin (4), veranisatin D (5), pseudomajucin (6), 1α-hydroxy-3-deoxy-pseudoanisatin (7), 8α-hydroxy-10-deoxycyclomerrillianolide (8) were isolated.
CONCLUSION:Compound 1 is new. Compounds 1, 2, 3, 5-8 were isolated from this plant for the first time. None of the isolates showed inhibitory effects on the growth of non-small cell lung tumor cell line A549.
